LMBB

Most of the contributors to this particular forum have medical degrees and can put these discussions in context.

I always respect an enquiring mind: with your current level of knowledge of this field, you need to be asking a lot more questions rather that delivering your opinions.

Keep enquiring.

"Cancer researchers" differentiate between mitogenesis and mutagenesis. You should, too. Cell division, generally, is a good thing: you'd be dead in days without it. Bandages have a number of roles: but "sun protection" would not rate in the top ten. PRP takes cells from one part of the body and re-delivers them to another - the net effect on carcinogenesis is exactly zero. laser treatments do not cause cancer unless they use a mutagenic wavelength: and no such laser is used in cosmetic dermatology (psoriasis and vitiligo aside). Retin-A is a free-radical scavenger/antioxidant - reduces cancer risk.

If you want to ask a question you might ask, for example: "PRP causes nothing but an erythrocyte-less bruise. Is there any evidence that such lesions cause cancer?" and the various doctors contributing to this forum would answer "No. We know of no evidence that repetitive bruising in a given location causes cancer. We are aware, as doctors, of Marjolin's ulcer, which is an SCC arising in an area of generally repeated trauma, but this is ectodermal, and most bruises are mesodermal, which is far less likely to give rise to cancer. For example, IV drug users, traumatising their cubital fossas several times per day, day after day, rarely if ever get cancers in their cubital fossas."

Keep asking. Keep learning. That's the way.

I've been performing PRP for orthopedic conditions for over four years and just over a year ago I started doing cosmetic PRP (the media calls it 'Dracula Therapy".

I have a page describing it on my website www.docereclinics.com.

It works amazingly well.

Dr Harry

Hi Topher

Do you have any before and afters that you could post?

10.19 | DID
Dr Shah,

I just got equipped with the "most popular" Korean PRP kit. You can find me at 20/F, Kailey Tower, Stranley St. Central, HK. Call 2890-8020, if you want to discuss anything.

Mahony,

I perfectly agree with what you said about: it is just simply how well you can retrieve the "platelet rich portion" rather than anything intrinsic of the tubes.

After asking more and more, it is clear to me what they are claiming : it is how well the tube's or the gel's design that "help you to retrieve the platlet rich portion, with the least difficulty, and the most consistency" for the average doctor.

I still believe that even with simple tubes, we can do the same PRP. But then again I am not sure if I can repeat and repeat again, with a similar concentration. So I bent my arms to accept that the tubes are just a tool to help me do it more easily, and "perhaps" with more consistency. And so I paid the money for the PRP set.

Ah, 1 more thing. I just been to the 1st internation conference of mini-invasive plastic surgery in Seoul, and I am led to believe that you need a "scaffolding" for the PRP to work, otrherwise the rejuvenation result is pretty minimal. The scalffoding can be a fat graft, a emusified fat gel, plasma gel, or HA gel. Now the Korean doctor I know is testing on giving GCSF-1 to a patient for 4 days to pump out the bone marrow stem cells, and then collect the blood for centrigugation, and collect the "stem cells buffy coat". Well again sound innovative to me, though I am not sure it will work. Thought stimulating though.

dr stephen

10.20 | dr stephen
Cancer researchers have known for years that any time you increase the number of cells dividing and growing, you increase the chances of cancer especially if you add sunlight to the mix. A wound/scab... on the face or arm has a greater chance of becoming cancerous esp. if exposed to sunlight. The risk is decreased if the wound is covered with a bandage so that it does not receive sunlight.
PRP adds an increased number of cells to an area, thus increasing the chances some could turn cancerous. Laser treatments cause wounds in the skin which then regenerate (dividing and growing) increasing the chances of cancer. Heck Retin-A increases cell growth and turnover and probably has the same results.
Having your patients avoid sunlight and tanning beds during the healing phase would drastically decrease the chances of cancer even more than the normal sun protection procedures that should be followed for everyone.

10.26 | LMBB
I forgot to add that while cancer might be possible, I would think it would be unlikely from these procedures esp. if they stay out of the sun while healing.

10.26 | LMBB
LMBB

Most of the contributors to this particular forum have medical degrees and can put these discussions in context.

I always respect an enquiring mind: with your current level of knowledge of this field, you need to be asking a lot more questions rather that delivering your opinions.

Keep enquiring.

"Cancer researchers" differentiate between mitogenesis and mutagenesis. You should, too. Cell division, generally, is a good thing: you'd be dead in days without it. Bandages have a number of roles: but "sun protection" would not rate in the top ten. PRP takes cells from one part of the body and re-delivers them to another - the net effect on carcinogenesis is exactly zero. laser treatments do not cause cancer unless they use a mutagenic wavelength: and no such laser is used in cosmetic dermatology (psoriasis and vitiligo aside). Retin-A is a free-radical scavenger/antioxidant - reduces cancer risk.

If you want to ask a question you might ask, for example: "PRP causes nothing but an erythrocyte-less bruise. Is there any evidence that such lesions cause cancer?" and the various doctors contributing to this forum would answer "No. We know of no evidence that repetitive bruising in a given location causes cancer. We are aware, as doctors, of Marjolin's ulcer, which is an SCC arising in an area of generally repeated trauma, but this is ectodermal, and most bruises are mesodermal, which is far less likely to give rise to cancer. For example, IV drug users, traumatising their cubital fossas several times per day, day after day, rarely if ever get cancers in their cubital fossas."

Keep asking. Keep learning. That's the way.

Keep enquiring.

"Cancer researchers" differentiate between mitogenesis and mutagenesis. You should, too. Cell division, generally, is a good thing: you'd be dead in days without it. Bandages have a number of roles: but "sun protection" would not rate in the top ten. PRP takes cells from one part of the body and re-delivers them to another - the net effect on carcinogenesis is exactly zero. laser treatments do not cause cancer unless they use a mutagenic wavelength: and no such laser is used in cosmetic dermatology (psoriasis and vitiligo aside). Retin-A is a free-radical scavenger/antioxidant - reduces cancer risk.

If you want to ask a question you might ask, for example: "PRP causes nothing but an erythrocyte-less bruise. Is there any evidence that such lesions cause cancer?" and the various doctors contributing to this forum would answer "No. We know of no evidence that repetitive bruising in a given location causes cancer. We are aware, as doctors, of Marjolin's ulcer, which is an SCC arising in an area of generally repeated trauma, but this is ectodermal, and most bruises are mesodermal, which is far less likely to give rise to cancer. For example, IV drug users, traumatising their cubital fossas several times per day, day after day, rarely if ever get cancers in their cubital fossas."

Keep asking. Keep learning. That's the way.

LMBB

Most of the contributors to this particular forum have medical degrees and can put these discussions in context.

I always respect an enquiring mind: with your current level of knowledge of this field, you need to be asking a lot more questions rather that delivering your opinions.

Keep enquiring.

"Cancer researchers" differentiate between mitogenesis and mutagenesis. You should, too. Cell division, generally, is a good thing: you'd be dead in days without it. Bandages have a number of roles: but "sun protection" would not rate in the top ten. PRP takes cells from one part of the body and re-delivers them to another - the net effect on carcinogenesis is exactly zero. laser treatments do not cause cancer unless they use a mutagenic wavelength: and no such laser is used in cosmetic dermatology (psoriasis and vitiligo aside). Retin-A is a free-radical scavenger/antioxidant - reduces cancer risk.

If you want to ask a question you might ask, for example: "PRP causes nothing but an erythrocyte-less bruise. Is there any evidence that such lesions cause cancer?" and the various doctors contributing to this forum would answer "No. We know of no evidence that repetitive bruising in a given location causes cancer. We are aware, as doctors, of Marjolin's ulcer, which is an SCC arising in an area of generally repeated trauma, but this is ectodermal, and most bruises are mesodermal, which is far less likely to give rise to cancer. For example, IV drug users, traumatising their cubital fossas several times per day, day after day, rarely if ever get cancers in their cubital fossas."

Keep asking. Keep learning. That's the way.

If you want to ask a question you might ask, for example: "PRP causes nothing but an erythrocyte-less bruise. Is there any evidence that such lesions cause cancer?" and the various doctors contributing to this forum would answer "No. We know of no evidence that repetitive bruising in a given location causes cancer. We are aware, as doctors, of Marjolin's ulcer, which is an SCC arising in an area of generally repeated trauma, but this is ectodermal, and most bruises are mesodermal, which is far less likely to give rise to cancer. For example, IV drug users, traumatising their cubital fossas several times per day, day after day, rarely if ever get cancers in their cubital fossas."

Keep asking. Keep learning. That's the way.

The growth factors, as I understand it, in PRP are active on the cell membrane, not on the nucleus or DNA. Therefore, there is no fear of mitosis "gone wild". I'll try to find the article where I read this.

I did try it on 3 Patients, I used Selphyl - www.selphyl.com, no results, quite expensive kit 375$ FOR 4cc of PRP. THE BOTTOM LINE DOES NOT WORK.

LMBB

Most of the contributors to this particular forum have medical degrees and can put these discussions in context.

I always respect an enquiring mind: with your current level of knowledge of this field, you need to be asking a lot more questions rather that delivering your opinions.

Keep enquiring.

"Cancer researchers" differentiate between mitogenesis and mutagenesis. You should, too. Cell division, generally, is a good thing: you'd be dead in days without it. Bandages have a number of roles: but "sun protection" would not rate in the top ten. PRP takes cells from one part of the body and re-delivers them to another - the net effect on carcinogenesis is exactly zero. laser treatments do not cause cancer unless they use a mutagenic wavelength: and no such laser is used in cosmetic dermatology (psoriasis and vitiligo aside). Retin-A is a free-radical scavenger/antioxidant - reduces cancer risk.

If you want to ask a question you might ask, for example: "PRP causes nothing but an erythrocyte-less bruise. Is there any evidence that such lesions cause cancer?" and the various doctors contributing to this forum would answer "No. We know of no evidence that repetitive bruising in a given location causes cancer. We are aware, as doctors, of Marjolin's ulcer, which is an SCC arising in an area of generally repeated trauma, but this is ectodermal, and most bruises are mesodermal, which is far less likely to give rise to cancer. For example, IV drug users, traumatising their cubital fossas several times per day, day after day, rarely if ever get cancers in their cubital fossas."

Keep asking. Keep learning. That's the way.

Keep enquiring.

"Cancer researchers" differentiate between mitogenesis and mutagenesis. You should, too. Cell division, generally, is a good thing: you'd be dead in days without it. Bandages have a number of roles: but "sun protection" would not rate in the top ten. PRP takes cells from one part of the body and re-delivers them to another - the net effect on carcinogenesis is exactly zero. laser treatments do not cause cancer unless they use a mutagenic wavelength: and no such laser is used in cosmetic dermatology (psoriasis and vitiligo aside). Retin-A is a free-radical scavenger/antioxidant - reduces cancer risk.

If you want to ask a question you might ask, for example: "PRP causes nothing but an erythrocyte-less bruise. Is there any evidence that such lesions cause cancer?" and the various doctors contributing to this forum would answer "No. We know of no evidence that repetitive bruising in a given location causes cancer. We are aware, as doctors, of Marjolin's ulcer, which is an SCC arising in an area of generally repeated trauma, but this is ectodermal, and most bruises are mesodermal, which is far less likely to give rise to cancer. For example, IV drug users, traumatising their cubital fossas several times per day, day after day, rarely if ever get cancers in their cubital fossas."

Keep asking. Keep learning. That's the way.

LMBB

Most of the contributors to this particular forum have medical degrees and can put these discussions in context.

I always respect an enquiring mind: with your current level of knowledge of this field, you need to be asking a lot more questions rather that delivering your opinions.

Keep enquiring.

"Cancer researchers" differentiate between mitogenesis and mutagenesis. You should, too. Cell division, generally, is a good thing: you'd be dead in days without it. Bandages have a number of roles: but "sun protection" would not rate in the top ten. PRP takes cells from one part of the body and re-delivers them to another - the net effect on carcinogenesis is exactly zero. laser treatments do not cause cancer unless they use a mutagenic wavelength: and no such laser is used in cosmetic dermatology (psoriasis and vitiligo aside). Retin-A is a free-radical scavenger/antioxidant - reduces cancer risk.

If you want to ask a question you might ask, for example: "PRP causes nothing but an erythrocyte-less bruise. Is there any evidence that such lesions cause cancer?" and the various doctors contributing to this forum would answer "No. We know of no evidence that repetitive bruising in a given location causes cancer. We are aware, as doctors, of Marjolin's ulcer, which is an SCC arising in an area of generally repeated trauma, but this is ectodermal, and most bruises are mesodermal, which is far less likely to give rise to cancer. For example, IV drug users, traumatising their cubital fossas several times per day, day after day, rarely if ever get cancers in their cubital fossas."

Keep asking. Keep learning. That's the way.

LMBB

Most of the contributors to this particular forum have medical degrees and can put these discussions in context.

I always respect an enquiring mind: with your current level of knowledge of this field, you need to be asking a lot more questions rather that delivering your opinions.

Keep enquiring.

"Cancer researchers" differentiate between mitogenesis and mutagenesis. You should, too. Cell division, generally, is a good thing: you'd be dead in days without it. Bandages have a number of roles: but "sun protection" would not rate in the top ten. PRP takes cells from one part of the body and re-delivers them to another - the net effect on carcinogenesis is exactly zero. laser treatments do not cause cancer unless they use a mutagenic wavelength: and no such laser is used in cosmetic dermatology (psoriasis and vitiligo aside). Retin-A is a free-radical scavenger/antioxidant - reduces cancer risk.

If you want to ask a question you might ask, for example: "PRP causes nothing but an erythrocyte-less bruise. Is there any evidence that such lesions cause cancer?" and the various doctors contributing to this forum would answer "No. We know of no evidence that repetitive bruising in a given location causes cancer. We are aware, as doctors, of Marjolin's ulcer, which is an SCC arising in an area of generally repeated trauma, but this is ectodermal, and most bruises are mesodermal, which is far less likely to give rise to cancer. For example, IV drug users, traumatising their cubital fossas several times per day, day after day, rarely if ever get cancers in their cubital fossas."

Keep asking. Keep learning. That's the way.

Patricia,

I know you went to a conference where they talked about the PRP but I am not sold on it at this point. I have talked to a number of physicians about PRP and at this time I cansider it mostly hype. I have not seen a good study or even impressive before and after pictures. I have looked at as many before and after pictures for facial PRP as I can find and have yet to find one that is "WOW". I have yet to find any before and after pictures that I do not have to search hard for any improvement.

So at this time I would tell you not to waste your money. They need to have good research and good long term studies before we all jump in. A lot of the information about PRP is all hype at this time and very little science.

This hype is what many of the companies are hoping for. They hope that they can get enough media buzz or buzz at these conferences and then we clinicians will follow in line like good sheepand purchase their product. Many of us jump on board because we want to be the first ones in our area to have and use the technology but the problem is that many times the newest does not turn out to be the best choice for our patients and we will never get the return on our money. Take a look at Zerona. It had a ton of hype behind it and sold many units and now one of the physicians that used to be a reference for them wrote a paper with others that showed Zerona had ZERO benefit.

I feel we need to hold off on this one at this time until they PROVE to us that it works and has long term positive benfits for the patient.

Lornell E. Hansen II, M.D.
Owner / Medical Director
LazaDerm Skincare Centre
www.LazaDerm.com

Hi everybody
would you please tel me to find a place ;where they offer a course on'' prp in cosmetic medicine '' and or ''fat prp'' in sydney-australia ?

Hi everybody
would you please tel me,
to Know about best setting of " relative centrifuge force" =G-FORCE?
MY centrifuge machine have from 1000 to 5000 RCF/G-FORCE, for setting .
Have any relation between RCF and results?
THIS IS MY E-MAIL LASERAGENT@YAHOO.COM .
I am waiting for your guidance
warmly regards MOHSEN

1000 rcf are too much for platelet concentration, optimal forces are distribuited among 150 to 400 g

Can someone tell me how old is this blog? Has PRP been used to treat skin conditions like Psoriasis?

Anybody here who has tried injecting platelet rich plasma right after fractional co2 laser? What are your recommendations?

We have been using Platelet Rich Plasma Therapy for Facial & Hair Rejuvenation. The early results have been promising.

Hello !
we are using PRP for aesthetic and medical indication about 6 months now.
@ jgy265 - there is a study about combining fractional Laser resurfacing with PRP: Shin, M.-K., Lee, J.-H., Lee, S.-J. and Kim, N.-I. (2012), Platelet-Rich Plasma Combined with Fractional Laser Therapy for Skin Rejuvenation. Dermatologic Surgery, 38: 623–630. doi: 10.1111/j.1524-4725.2011.02280.x
(http://onlinelibrary.wiley.com/doi/10.1111/j.1524-4725.2011.02280.x/abstract;jsessionid=DCD33B23A843A023D783F0A18F3135F7.d02t04)
@ Marlene - I do not think it helps for psoriasis (did not tried it)
@ Dr. Harry - Great homepage !

We use it for mesotherapy with PRP, mixed with hyaluronisc acid as a "enhanced" filler, after fractional Co2 laser or fractional radiofrequency therapy and for treating hair loss as mesotherapy injections or medical purposes treating leg ulcera or generally not healing wounds.
We have a relative cheap centrifuge (about 1400 euros) and a PRP system that costs about 70€ /set (or less if you buy more). I think the advantage of this system, compared with other, is that the system is closed and the PRP is safe and of very good quality. We buy it in Germany here: http://romedtech.de/produkte/superprp.html

I think there are a lot of studys out there like: http://www.ncbi.nlm.nih.gov/pubmed/22455565, http://www.ncbi.nlm.nih.gov/pubmed?term=prp%20rejuvenation
but it is a safe procedure that is improving the skin but is not comparable with a surgical lift. Most patients are happy with it.

we have been using prp for reconstructive rather than cosmetic purposes. can you share tips on how to achieve optimum results and avoid complications when applying it on the face?

rauscher,
i'm starting to do prp at my practice for hair loss treatment, the result with 3 patient is promising, but i'm not sure whether it's prp or the topical treatment that working. how do you do hair rejuvenation , prp only or combined with other medication?

also prp for filler, how do you use it with HA filler? same time or as booster different day? do you heat the prp to form filler consistency or using special tube for prp filler? i'm using regen kit now.

thanks

Hi all, the latest PRP device is the Medifuge made by Silfradent ( Italy ) that creates optimal concentrate growth factors with CD35+ positive stem cell. A liquified and/or Fibrin phase. with a positive outcome. The cost of sundries which includes vacuette tubes etc... is only a few dollars, l am selling unit in Australia... ref for Kylie most likely Medigufe was used. Presently unit is used by many happy dentist here but haven't exploited sale for other application

ref to Dr Azish...contact me 02 95882794...u don't need to attend a course, its so simple

Supenova... u only inject the liquified phase of c.g.f. can aslo use fibrin to roll over the skin... .... a Perth doctor eye lashes from an injry re_grew after 20 years...

hi all...If any wants to do trials for publications or Academic research .....using Medifuge in Australia let me know. I much believe generates the optimal concentrate of growth factors plus CD34 positive cell...... with a postive outcome
A liquified phase or a Fibrin phase : a 100% Autologous protocol with a few dollars of sundries
let me know ph 02 95882794 or brunon@cubicdental.com.au
Much appreciate

A Medifuge is a plasma phase separator a patented centrifugation protocol.. beter than PRP units. Will cost you $4950. Use g standard sundries required for liquidfied phase, each evacuate tube cost about $1....no bad that is it. and outcome will bring a smile

Hi! Does anybody used medical device Angel PRP from Cytomedix for orthopaedic use? For knee OA, btw.

Injectable Concentrated growth factors with CD34+ stem cells
protocol using the Medifuge ( made by Silfradent Italy ) is more expensive than a PRP unit
but the sundries " vacuette tubes" - White or Green cap ( with inhibitor ) are cheap and readily available
and has best c.g.fs' , also using Red cap vacu_tube you generate a good fibrin block matrix

Hello,
the mails from this forum landed in my spam and did not noticed them.
@ Supernova
- With the Kits that I am using I get "therapeutic" PRP (about 5x more platelets as in the normal blood). There is a general consensus that this is the optimal concentration. More concentration tend to destroy the platelets. For the hair loss treatment I use sometimes PRP alone and sometimes combined with microneedling. I use 2-4 ml therapeutic PRP (1-2 Kits) and injekt this in the dermis-subcutis . Some patients like the mesogun some like injections made by free hand. Because the patient should do something himself I encourage them to use Regaine. The majority of patients already used Regaine before they come to me, so I am pretty sure that the good results are done by PRP. I am not very sure how often should be PRP used. I am doing at least 3 sessions 3 weeks apart.
- Filler: I am injecting the HA deep and the PRP superficial. The PRP should induce the production of new collagen. I am doing this in the same session because the patients do not want to come twice. I do not see any problem in doing both.
During the patients waits for the numbing cream to work we prepare the PRP.
I do not heat the PRP. I do not believe in Plasmagel.
The living platelets should release growth factors. Why heating them ?
@ Christina Bumbaru
PRP is PRP the one we use is suitable for orthopaedic use. My neighbor is Orthopedist and we use both the same kits ;-)
He uses more kits then me so it seems to work..

Dr Azish
Ref to PRP in Sydney
Ring 02 - 95882794